• Product NameZonisamide
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityZonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
• Target NameCalcium Channel inhibitor; Carbonic Anhydrase inhibitor; Sodium Channel inhibitor
• CAS No. 68291-97-4
• Calculated MW 212.23
• Formulation C8H8N2O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:NS(=O)(=O)CC1=NOC2=CC=CC=C12
  Pathways:Membrane transporter/Ion channel; Metabolism
  Receptor:Calcium Channel; Carbonic anhydrase; Sodium Channel
  Boling pt:
  Melting pt:275C?
  Solubility:Ethanol: 5 mg/mL (23.55 mM); DMSO: 42 mg/mL (197.89 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tsujii S, et al. Eur J Pharmacol. 2015 Jan 5;746:301-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting