• Product NameQ-VD-OPH
• Brief DescriptionInhibitors
• Purification97.80%
• Biological ActivityQ-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 1, 3, 8 and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively.
• Target NameCaspase inhibitor
• CAS No. 1135695-98-5
• Calculated MW 513.5
• Formulation C26H25F2N3O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
  Pathways:Apoptosis; Proteases/Proteasome
  Receptor:Caspase-1; Caspase-3; Caspase-8; Caspase-9
  Boling pt:
  Melting pt:
  Solubility:DMSO: 25 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rohn TT, et al. Caspase activation in transgenic mice with Alzheimer-like pathology: results from a pilot study utilizing the caspase inhibitor, Q-VD-OPh. Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting