• Product NameClofarabine
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityClofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 123318-82-1
• Calculated MW 303.68
• Formulation C10H11ClFN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl
  Pathways:DNA Damage/DNA Repair
  Receptor:RR
  Boling pt:550C?
  Melting pt:228-231C
  Solubility:DMSO: 60 mg/mL (197.57 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bonate PL, et al. Nat Rev Drug Discov, 2006, 5(10), 855-863.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting