• Product NameNimodipine
• Brief DescriptionInhibitors
• Purification99.56%
• Biological ActivityNimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
• Target NameAhR agonist; Calcium Channel inhibitor; Glucocorticoid Receptor antagonist
• CAS No. 66085-59-4
• Calculated MW 418.44
• Formulation C21H26N2O7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C
  Pathways:Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism
  Receptor:AhR; Calcium Channel; Mineralocorticoid Receptor
  Boling pt:
  Melting pt:125C
  Solubility:Ethanol: 84 mg/mL (200.74 mM); DMSO: 84 mg/mL (200.74 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Weant KA, et al. PharmacOthersapy. 2010 Apr;30(4):405-17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting