• Product NameGliquidone
• Brief DescriptionInhibitors
• Purification99.93%
• Biological ActivityGliquidone is an anti-diabetic drug in the sulfonylurea class. It is used in the treatment of diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
• Target NamePotassium Channel antagonist
• CAS No. 33342-05-1
• Calculated MW 527.63
• Formulation C27H33N3O6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:COC1=CC2=C(C=C1)C(C)(C)C(=O)N(CCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1)C2=O
  Pathways:Membrane transporter/Ion channel
  Receptor:Potassium Channel
  Boling pt:
  Melting pt:179C
  Solubility:Ethanol: 6 mg/mL (11.37 mM); DMSO: 105 mg/mL (199.0 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Angel I, et al. Fundam Clin Pharmacol, 1991, 5(2), 107-115.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting