• Product NameErlotinib
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityErlotinib (OSI-744; NSC 718781; R1415) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
• Target NameEGFR inhibitor
• CAS No. 183321-74-6
• Calculated MW 393.44
• Formulation C22H23N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR
  Boling pt:553.6C?
  Melting pt:223 - 228C
  Solubility:Ethanol: 15 mg/mL warmed (38.12 mM); DMSO: 78 mg/mL (198.25 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Moyer JD, et al. Y Res. 1997, 57(21), 4838-4848.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting