• Product NameErlotinib hydrochloride
• Brief DescriptionInhibitors
• Purification99.52%
• Biological ActivityErlotinib is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM. Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung Y, pancreatic Yand several other types of Y.
• Target NameEGFR inhibitor
• CAS No. 183319-69-9
• Calculated MW 429.9
• Formulation C22H23N3O4HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR/HER1
  Boling pt:553.6C
  Melting pt:223-225C
  Solubility:DMSO: 3 mg/mL (6.97 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Moyer JD, et al. Y Res. 1997, 57(21), 4838-4848.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting