• Product NameSunitinib Malate
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPotent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor. Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.
• Target NameFGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 341031-54-7
• Calculated MW 532.56
• Formulation C26H33FN4O7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; PDGFRβ; VEGFR2
  Boling pt:
  Melting pt:189-191C
  Solubility:DMSO: 15 mg/mL (28.16 mM)
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting