• Product NameSunitinib
• Brief DescriptionInhibitors
• Purification99.67%
• Biological ActivitySunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
• Target Namec-Kit inhibitor; FLT inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 557795-19-4
• Calculated MW 398.47
• Formulation C22H27FN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; FLT3; PDGFRβ; VEGFR2
  Boling pt:572.1C
  Melting pt:189-191C
  Solubility:DMSO: 25 mg/mL warmed (62.73 mM)
  Appearance:Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting