• Product NamePCI-24781 (Abexinostat)
• Brief DescriptionInhibitors
• Purification98.43%
• Biological ActivityPCI-24781 (Abexinostat) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.
• Target NameHDAC inhibitor
• CAS No. 783355-60-2
• Calculated MW 397.42
• Formulation C21H23N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)CC1C2CCCCC2OC1C(=O)NCCOC1=CC=C(C=C1)C(=O)NO
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC10; HDAC2; HDAC3/SMRT; HDAC6
  Boling pt:
  Melting pt:
  Solubility:DMSO: 80 mg/mL (201.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Buggy JJ, et al. Mol Y Ther, 2006, 5(5), 1309-1317.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting