• Product NameCarvedilol
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCarvedilol(BM14190) is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.
• Target NameAdrenergic Receptor inhibitor; HIF modulator; Integrin inhibitor; NADPH inhibitor; Others inhibitor; Potassium Channel inhibitor; VEGFR inhibitor
• CAS No. 72956-09-3
• Calculated MW 406.47
• Formulation C24H26N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2
  Pathways:Angiogenesis; Neuroscience; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Others; Chromatin/Epigenetic; GPCR/G Protein; Tyrosine Kinase/Adaptors
  Receptor:Adrenergic Receptor; HIF; E-selectin; NADPH; Vcam; Potassium Channel; VEGFR
  Boling pt:655.2C
  Melting pt:113-117C
  Solubility:Ethanol: 4 mg/mL (9.84 mM); DMSO: 81 mg/mL (199.27 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Koshimizu TA, et al. Cardiovasc Res. 2004 Sep 1; 63(4):662-72.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting