• Product NameIndometacin
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityIndomethacin is a non-steroidal antiinflammatory agent (NSAIA) with antiinflammatory, analgesic and antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway.
• Target NameCOX inhibitor; PDE antagonist; Phospholipase inhibitor
• CAS No. 53-86-1
• Calculated MW 357.79
• Formulation C19H16ClNO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O
  Pathways:Immunology/Inflammation; Metabolism; Neuroscience
  Receptor:COX-1; COX-1; COX-2; PDE2; PLA2
  Boling pt:
  Melting pt:155-162C
  Solubility:Ethanol: 24 mg/mL (67.07 mM); DMSO: 72 mg/mL (201.23 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mitchell JA, et al. Proc Natl Acad Sci U S A. 1993, 90(24), 11693-11697.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting