• Product NameAbbolactone
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityA potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827).
• Target NameAndrogen Receptor antagonist
• CAS No. 1952-1-7
• Calculated MW 416.57
• Formulation C24H32O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
  Pathways:Endocrinology/Hormones
  Receptor:Androgen Receptor
  Boling pt:597C
  Melting pt:207-208C
  Solubility:Ethanol: 20 mg/mL (48.01 mM); DMSO: 83 mg/mL (199.24 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ye P, et al. Horm Metab Res. 2009 Jan;41(1):35-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting