• Product NameZileuton
• Brief DescriptionInhibitors
• Purification99.43%
• Biological ActivityZileuton (A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
• Target NameCOX inhibitor; Lipoxygenase inhibitor
• CAS No. 111406-87-2
• Calculated MW 236.29
• Formulation C11H12N2O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system
  SMILES:CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1
  Pathways:Immunology/Inflammation; Metabolism; Neuroscience
  Receptor:COX-1; 5-Lipoxygenase
  Boling pt:449.4C?
  Melting pt:157-158C
  Solubility:Ethanol: 47 mg/mL (198.9 mM); DMSO: 47 mg/mL (198.9 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rossi A1, et al. Br J Pharmacol, 2010, 161(3), 555-570.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting