• Product NameCytisine
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost.
• Target NameAChR agonist
• CAS No. 485-35-8
• Calculated MW 190.25
• Formulation C11H14N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1[C@H]2CNC[C@@H]1C3=CC=CC(=O)N3C2
  Pathways:Neuroscience
  Receptor:nAChR
  Boling pt:218C
  Melting pt:154-156C
  Solubility:Ethanol: 38 mg/mL (199.74 mM); Water: 38 mg/mL (199.74 mM); DMSO: 38 mg/mL (199.74 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Walker N, et al. N Engl J Med. 2014 Dec 18;371(25):2353-62.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting