• Product NameIrinotecan hydrochloride trihydrate
• Brief DescriptionInhibitors
• Purification99.78%
• Biological ActivityIrinotecan Hcl-trihydrate prevents DNA from unwinding by inhibition of topoisomerase 1.
• Target NameTopoisomerase inhibitor
• CAS No. 136572-09-3
• Calculated MW 677.18
• Formulation C33H45ClN4O9
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo I
  Boling pt:873.4C?
  Melting pt:250-256C?
  Solubility:Ethanol: 7 mg/mL (10.33 mM); Water: 1 mg/mL (1.47 mM); DMSO: 100 mg/mL (147.67 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tsuruo T, et al. Y ChemOthers Pharmacol. 1988;21(1):71-4.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting