• Product NameIrinotecan Hydrochloride
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIrinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.
• Target NameTopoisomerase inhibitor
• CAS No. 100286-90-6
• Calculated MW 623.14
• Formulation C33H39ClN4O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo I
  Boling pt:
  Melting pt:
  Solubility:Soluble in Water
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yoshikawa M, et al. Int J Y. 2004 Jul 20;110(6):921-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting