• Product NameDimethyl fumarate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityDimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
• Target NameOthers
• CAS No. 624-49-7
• Calculated MW 144.13
• Formulation C6H8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:COC(=O)/C=C/C(=O)OC
  Pathways:Others
  Receptor:KEAP1-Nrf2
  Boling pt:192-193C
  Melting pt:102-106C
  Solubility:Ethanol: 10 mg/mL (69.38 mM); DMSO: 29 mg/mL (201.2 mM)
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Oh CJ, et al. PLoS One. 2012;7(10):e45870.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting