• Product NameLamotrigine
• Brief DescriptionInhibitors
• Purification99.76%
• Biological ActivityLamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown.
• Target Name5-HT Receptor antagonist
• CAS No. 84057-84-1
• Calculated MW 256.09
• Formulation C9H7Cl2N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT (human platelets); 5-HT (rat brain synaptosomes)
  Boling pt:503.1C
  Melting pt:177-181C
  Solubility:Ethanol: 3 mg/mL (11.71 mM); DMSO: 10 mg/mL (39.04 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lipkind GM, et al. Mol Pharmacol. 2005 Dec;68(6):1611-22.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting