• Product NameSimvastatin
• Brief DescriptionInhibitors
• Purification98.54%
• Biological ActivitySimvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity.
• Target NameHMG-CoA Reductase inhibitor
• CAS No. 79902-63-9
• Calculated MW 418.57
• Formulation C25H38O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
  Pathways:Metabolism
  Receptor:HMG-CoA reductase
  Boling pt:
  Melting pt:139C
  Solubility:Ethanol: 83 mg/mL (198.29 mM); DMSO: 83 mg/mL (198.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Slater EE, et al. Drugs. 1988, 36 Suppl 3, 72-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting