• Product NamePranlukast
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
• Target NameIL Receptor inhibitor; LTR antagonist; NF-κB inhibitor; Others inhibitor; TNF inhibitor
• CAS No. 103177-37-3
• Calculated MW 481.5
• Formulation C27H23N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system
  SMILES:O=C(NC1=CC=CC2=C1OC(=CC2=O)C1=NNN=N1)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1
  Pathways:Apoptosis; Immunology/Inflammation; NF-κb; Others
  Receptor:IL-5; CysLTR; NF-κB; Eosinophil cationic protein; Mucin-2; TNF-α
  Boling pt:
  Melting pt:236-238C
  Solubility:DMSO: 11mg/ml(22.85 mM);Water: <1mg/ml;Ethanol: <1mg/ml
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yoo SH, et al. Respirology. 2001 Mar;6(1):15-21.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting