• Product NamePMSF
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPMSF (Phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy. It has a role in a lot of cellular repair and regeneration processes in many kinds of tissues. PMSF is a long acting Neuropathy Target Esterase (NTE) inhibitor. NTE is a protection was related to inhibition of the putative target of organophosphate-induced delayed polyneuropathy (OPIDP). PMSF can increase NTE inhibition to more than 90%. PMSF also acts as an active site directed reagent for γ-glutamyl transpeptidase.
• Target NameCysteine Protease inhibitor; Serine Protease inhibitor
• CAS No. 329-98-6
• Calculated MW 174.19
• Formulation C7H7FO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FS(=O)(=O)CC1=CC=CC=C1
  Pathways:Proteases/Proteasome
  Receptor:Cysteine protease; Serine Protease
  Boling pt:112C
  Melting pt:92-95C
  Solubility:Ethanol: 15 mg/mL (86.11 mM); DMSO: 35 mg/mL (200.93 mM)
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Compton DR, et al. J Pharmacol Exp Ther, 1997, 283(3), 1138-1143.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting