• Product NameQuinapril hydrochloride
• Brief DescriptionInhibitors
• Purification98.76%
• Biological ActivityQuinapril hydrochloride (Accupril) used in the treatment of hypertension and congestive heart failure. Quinapril is a prodrug. Quinapril is converted to its active metabolite, quinaprilat, in the liver. Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
• Target NameRAAS inhibitor
• CAS No. 82586-55-8
• Calculated MW 474.98
• Formulation C25H31CIN2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O.Cl
  Pathways:Endocrinology/Hormones
  Receptor:ACE
  Boling pt:
  Melting pt:120-130C
  Solubility:Ethanol: 95 mg/mL (200.0 mM); Water: 95 mg/mL (200.0 mM); DMSO: 18 mg/mL (37.89 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Watson AM, et al. Atherosclerosis. 2014 Aug;235(2):444-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting