• Product NameFurosemide
• Brief DescriptionInhibitors
• Purification99.40%
• Biological ActivityFurosemide is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
• Target NameNa-K-Cl cotransporter antagonist
• CAS No. 54-31-9
• Calculated MW 330.74
• Formulation C12H11ClN2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O
  Pathways:Membrane transporter/Ion channel
  Receptor:Na-K-Cl cotransporter
  Boling pt:
  Melting pt:220C?
  Solubility:DMSO: 66 mg/mL (199.55 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vormfelde SV, et al. Clin Pharmacol Ther. 2007 Sep;82(3):300-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting