• Product NameHomotaurine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBecause of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.
• Target NameBeta Amyloid inhibitor; GABA Receptor agonist
• CAS No. 3687-18-1
• Calculated MW 139.17
• Formulation C3H9NO3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:NCCCS(O)(=O)=O
  Pathways:Membrane transporter/Ion channel; Neuroscience
  Receptor:Aβ; GABA
  Boling pt:
  Melting pt:293C
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fariello RG, et al. Neurology, 1982, 32 (3): 241C5.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting