• Product NameCyclosporin A
• Brief DescriptionInhibitors
• Purification99.85%
• Biological ActivityCyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.
• Target Namephosphatase inhibitor
• CAS No. 59865-13-3
• Calculated MW 1202.64
• Formulation C62H111N11O12
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
  Pathways:Others
  Receptor:calcineurin phosphatase
  Boling pt:1293.8C
  Melting pt:148-151C
  Solubility:Ethanol: 100 mg/mL warmed (83.15 mM); DMSO: 100 mg/mL warmed (83.15 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Handschumacher RE, et al. Science, 1984, 226(4674), 544-547.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting