• Product NamePaclitaxel
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPaclitaxel is a novel antineoplastic agent, which was discovered in a screen of extracts of thousands of plants and natural products for antineoplastic activity by a National Y Institute program. Alought it functions as a mitotic inhibitor like vinca alkaloids, paclitaxel promotes the polymerization of tubulin instead of inducing the disassembly of microtubules, which inhibits the microtubules disassembly and promotes the formation of excessively stable, dysfunctional microtubules. Paclitaxel has exhibited antitumor activity against a broad spectrum of human Ys, including ovarian, breast, head and neck, and lung Y, in a large number of studies.
• Target NameMicrotubule Associated inhibitor
• CAS No. 33069-62-4
• Calculated MW 853.92
• Formulation C47H51NO14
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
  Pathways:Cytoskeletal Signaling
  Receptor:microtubule
  Boling pt:957.12C
  Melting pt:213C
  Solubility:Ethanol: 18 mg/mL (21.07 mM); DMSO: 171 mg/mL (200.25 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang J, et al. AntiY Drugs. 2003, 14(1), 13-19.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting