• Product NameRoflumilast
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityRoflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.
• Target NamePDE inhibitor
• CAS No. 162401-32-3
• Calculated MW 403.21
• Formulation C17H14Cl2F2N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system
  SMILES:FC(F)OC1=C(OCC2CC2)C=C(C=C1)C(=O)NC1=C(Cl)C=NC=C1Cl
  Pathways:Metabolism
  Receptor:PDE4A1; PDE4A4; PDE4B1; PDE4B2; PDE4C1
  Boling pt:470.9C
  Melting pt:158C
  Solubility:Ethanol: 15 mg/mL (37.2 mM); DMSO: 81 mg/mL (200.88 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Barone FC, et al. Pharmacology. 2007 Aug 28;81(1):11-17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting