• Product NameGranisetron hydrochloride
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityGranisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. IC50 Value: 17uM (GR reduced 5-HT-evoked contractions)
• Target Name5-HT Receptor antagonist
• CAS No. 107007-99-8
• Calculated MW 348.87
• Formulation C18H25ClN4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.CN1N=C(C(=O)NC2CC3CCCC(C2)N3C)C2=CC=CC=C12
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT
  Boling pt:532C?
  Melting pt:290-292C
  Solubility:Ethanol: 1 mg/mL (2.86 mM); Water: 70 mg/mL (200.64 mM); DMSO: 1 mg/mL (2.86 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Turvill JL, et al. Br J Pharmacol. 2000 Jul;130(5):1031-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting