• Product NameTretinoin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAn important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
• Target NameRetinoid Receptor agonist
• CAS No. 302-79-4
• Calculated MW 300.44
• Formulation C20H28O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
  Pathways:Metabolism
  Receptor:RAR
  Boling pt:462.8C
  Melting pt:180-181C
  Solubility:Ethanol: 6 mg/mL (19.97 mM); DMSO: 60 mg/mL (199.73 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting