• Product NameTheophylline monohydrate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityA methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
• Target NameAChR inhibitor; HDAC activator; PDE inhibitor
• CAS No. 5967-84-0
• Calculated MW 198.18
• Formulation C7H8N4O2H2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system
  SMILES:O.CN1C2=C(NC=N2)C(=O)N(C)C1=O
  Pathways:Chromatin/Epigenetic; Metabolism; Neuroscience; DNA Damage/DNA Repair; NF-κb
  Receptor:Adenosine receptor; HDAC2; PDE
  Boling pt:454.1C
  Melting pt:270-274C
  Solubility:Soluble in Water
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nantwi KD, et al. J Spinal Cord Med. 2003 Winter;26(4):364-71.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting