• Product NameMifepristone
• Brief DescriptionInhibitors
• Purification99.76%
• Biological ActivityMifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
• Target NameEstrogen/progestogen Receptor antagonist; GR antagonist
• CAS No. 84371-65-3
• Calculated MW 429.6
• Formulation C29H35NO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
  Pathways:Endocrinology/Hormones; Metabolism
  Receptor:PR; Glucocorticoid Receptor
  Boling pt:628.6C
  Melting pt:195-198C
  Solubility:Ethanol: 19 mg/mL (44.22 mM); DMSO: 85 mg/mL (197.86 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jiang W, et al. Bioorg Med Chem, 2006, 14(19), 6726-6732.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting