• Product NamePodophyllotoxin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPodophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
• Target NameMicrotubule Associated inhibitor; Topoisomerase inhibitor
• CAS No. 518-28-5
• Calculated MW 414.41
• Formulation C22H22O8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O
  Pathways:Cytoskeletal Signaling; DNA Damage/DNA Repair
  Receptor:microtubule; Topo II
  Boling pt:597.9C?
  Melting pt:183-184C
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang YL, et al. J Nat Prod. 1992 Aug; 55(8):1100-11.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting