• Product NameBenfotiamine
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBenfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy, can inhibit three major pathways(the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)?protein kinase C (PKC) pathwayof hyperglycemic damage and prevent experimental diabetic retinopathy. Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) for treating sciatica and other painful nerve conditions. More effective at increasing thiamin levels in blood and tissues than water-soluble salts like the previous vitamin B1.
• Target NameOthers inhibitor
• CAS No. 22457-89-2
• Calculated MW 466.46
• Formulation C19H23N4O6PS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:CC(N(CC1=CN=C(C)N=C1N)C=O)=C(CCOP(O)(O)=O)SC(=O)C1=CC=CC=C1
  Pathways:Others
  Receptor:Others
  Boling pt:745.1C
  Melting pt:165C
  Solubility:Soluble in DMSO
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bozic I, et al. PLoS One. 2015 Feb 19;10(2):e0118372.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting