• Product NameNimesulide
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
• Target NameCOX inhibitor
• CAS No. 51803-78-2
• Calculated MW 308.31
• Formulation C13H12N2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
  Pathways:Immunology/Inflammation; Neuroscience
  Receptor:COX-2
  Boling pt:442C?
  Melting pt:140-146C
  Solubility:DMSO: 62 mg/mL (201.09 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rainsford KD. Curr Med Res Opin. 2006 Jun;22(6):1161-70.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting