• Product NamePalonosetron hydrochloride
• Brief DescriptionInhibitors
• Purification99.84%
• Biological ActivityPalonosetron (INN, trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its class approved for this use by the U.S. Food and Drug Administration. As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.
• Target Name5-HT Receptor antagonist
• CAS No. 135729-62-3
• Calculated MW 332.87
• Formulation C19H24N2OHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1C[C@@H]2CN(C(=O)C3=C2C(=CC=C3)C1)[C@@H]4CN5CCC4CC5.Cl
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT
  Boling pt:470.4C?
  Melting pt:>290C
  Solubility:Water: 67 mg/mL (201.27 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Grunberg SM, Koeller JM. Expert Opin PharmacOthers. 2003 Dec;4(12):2297-303.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting