• Product NameEllipticine
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityEllipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 1.250.13, 0.670.06, 1.250.13, 0.670.06, 0.270.02, 0.440.03, 0.490.04, and 1.480.62 μM for Breast adenocarcinoma MCF-7, Leukemia HL-60, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-3, Neuroblastoma UKF-NB-4, and Glioblastoma U87MG cell, respectively.
• Target NameTopoisomerase inhibitor
• CAS No. 519-23-3
• Calculated MW 246.31
• Formulation C17H14N2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C2NC3=CC=CC=C3C2=C(C)C2=C1C=CN=C2
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo II
  Boling pt:
  Melting pt:316-318C
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Savorani C, et al. Leuk Lymphoma. 2015 Mar;56(3):739-47.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting