• Product NameTopotecan hydrochloride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityTopotecan HCl (SKF 104864A; NSC 609669) is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
• Target NameTopoisomerase inhibitor
• CAS No. 119413-54-6
• Calculated MW 457.92
• Formulation C23H24ClN3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo I (DU-145 Luc cells); Topo I (MCF-7 Luc cells)
  Boling pt:782.9C
  Melting pt:213-218C
  Solubility:Water: 92 mg/mL (200.91 mM); DMSO: 92 mg/mL (200.91 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Caceres G, et al. AntiY Drugs. 2003, 14(7), 569-574.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting