• Product NameAmsacrine
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityAmsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II.
• Target NamePotassium Channel inhibitor; Topoisomerase inhibitor
• CAS No. 51264-14-3
• Calculated MW 393.46
• Formulation C21H19N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=C3C=CC=CC3=NC3=CC=CC=C23)C=CC(NS(C)(=O)=O)=C1
  Pathways:DNA Damage/DNA Repair; Membrane transporter/Ion channel
  Receptor:Potassium Channel; Topo II
  Boling pt:563C
  Melting pt:230-240C
  Solubility:DMSO: 9.3 mg/mL
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Thomas D, et al. Br J Pharmacol. 2004 Jun;142(3):485-94.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting