• Product NameMegestrol acetate
• Brief DescriptionInhibitors
• Purification99.72%
• Biological ActivityMegestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast Y. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
• Target NameEstrogen/progestogen Receptor agonist; GR inhibitor
• CAS No. 595-33-5
• Calculated MW 384.51
• Formulation C24H32O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
  Pathways:Endocrinology/Hormones; Metabolism
  Receptor:ER; Glucocorticoid Receptor
  Boling pt:
  Melting pt:214C
  Solubility:Ethanol: 15 mg/mL (39.01 mM); DMSO: 33 mg/mL (85.82 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vadivelu S, et al. J Neurosurg. 2010 May;112(5):920-4.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting