• Product NameOrphenadrine hydrochloride
• Brief DescriptionInhibitors
• Purification99.40%
• Biological ActivityOrphenadrine is an anticholinergic drug of the ethanolamine antihistamine class with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions, as well as the treatment of some aspects of Parkinson's disease. It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's, such as benztropine and trihexyphenidyl, and it is also structurally related to nefopam, which is a centrally acting yet nonopioid analgesic. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches
• Target NameHistamine Receptor antagonist; NMDAR antagonist; Norepinephrine antagonist; Sodium Channel inhibitor
• CAS No. 341-69-5
• Calculated MW 305.85
• Formulation C18H23NOHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1C
  Pathways:GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Immunology/Inflammation
  Receptor:H1 receptor; NMDA receptor; Noradrenaline transporter (Sodium-dependent); Sodium Channel
  Boling pt:363C
  Melting pt:156-157C
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kornhuber J, et al. J Neural Transm Gen Sect. 1995;102(3):237-46.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting