• Product NamePyrazinamide
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityPyrazinamide (Pyrazinoic acid amide) is an agent used to treat tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which is only active in acidic conditions. Pyrazinamidase converts pyrazinamide (Pyrazinoic acid amide) to the active form, pyrazinoic acid which accumulates in the bacilli. Pyrazinoic acid inhibits the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted.
• Target NameFatty Acid Synthase inhibitor
• CAS No. 98-96-4
• Calculated MW 123.11
• Formulation C5H5N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system
  SMILES:NC(=O)C1=NC=CN=C1
  Pathways:Metabolism
  Receptor:FAS
  Boling pt:412.7C
  Melting pt:102-106C
  Solubility:Ethanol: 2 mg/mL (16.24 mM); Water: 12 mg/mL (97.47 mM); DMSO: 25 mg/mL (203.07 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zimhony O, et al. Nat Med. 2000 Sep; 6(9):1043-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting