• Product NameMemantine hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMemantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics. Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer's disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine
• Target NameGluR inhibitor; NMDAR inhibitor; Others antagonist
• CAS No. 41100-52-1
• Calculated MW 215.76
• Formulation C12H22ClN
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2
  Pathways:Neuroscience; Others
  Receptor:AMPA; NMDA receptor; Kainate receptor
  Boling pt:239.8C?
  Melting pt:292C
  Solubility:Ethanol: 43 mg/mL (199.29 mM); Water: 30 mg/mL (139.04 mM); DMSO: 43 mg/mL (199.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bresink I, et al. British journal of pharmacology, 1996, 119(2): 195-204.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting