• Product NameAgomelatine
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAgomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was discovered and developed by the European pharmaceutical company Servier Laboratories Ltd. Servier continue to develop the drug and conduct phase III trials in the European Union.
• Target Name5-HT Receptor antagonist
• CAS No. 138112-76-2
• Calculated MW 243.3
• Formulation C15H17NO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:COC1=CC2=C(C=CC=C2CCNC(C)=O)C=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT
  Boling pt:478.8C?
  Melting pt:107-109C
  Solubility:Ethanol: 49 mg/mL (201.39 mM); DMSO: 49 mg/mL (201.39 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Millan MJ, et al. Psychopharmacology (Berl). 2005, 177(4):448-58.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting