• Product NameProcarbazine hydrochloride
• Brief DescriptionInhibitors
• Purification85.01%
• Biological ActivityProcarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. Procarbazine interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis. Procarbazine hydrochloride (Matulane) is used in the treatment of Hodgkins lymphoma and other malignant lymphomas including:- lymphosarcoma- reticulosarcoma- Brill-Symmers disease. Because procarbazine hydrochloride (Matulane) works differently to other antiY agents,Procarbazine hydrochloride (Matulane) may be useful in the treatment of Ys that have not responded to other treatments.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 366-70-1
• Calculated MW 257.76
• Formulation C12H19N3OHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C
  Pathways:DNA Damage/DNA Repair
  Receptor:DNA/RNA Synthesis
  Boling pt:612.3C?
  Melting pt:223C
  Solubility:Ethanol: 52 mg/mL (201.73 mM); Water: 52 mg/mL (201.73 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ogawa K, et al. Mutat Res. 2003 Aug 5;539(1-2):145-55.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting