- Product NameBH3I-1
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityBH3I-1 is a Bcl-2 family inhibitor. BH3I-1 appeared to induce a dose- and time-dependent apoptosis in H460 and H1792 cells, regardless of p53 status. After 2 days of BH3I-1 treatment, the cells that remained attached were exposed to ionizing radiation. Followed by clonogenic assay, BH3I-1 treatment enhanced the radiation sensitivity of H1792 surviving cells with mutant p53, but not in H460 cells with wild-type p53. A transient time-dependent cell cycle blockade at G2-M phase was identified for H1792 cells without subsequent modification of cell cycle distribution.
- Target NameBcr-Abl inhibitor; Mdm2 inhibitor
- CAS No. 300817-68-9
- Calculated MW 400.31
- Formulation C15H14BrNO3S2
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
