• Product NameDutasteride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityDutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.
• Target NameReductase inhibitor
• CAS No. 164656-23-9
• Calculated MW 528.53
• Formulation C27H30F6N2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
  Pathways:Endocrinology/Hormones; Enzyme
  Receptor:5-α reductase
  Boling pt:620.3C?
  Melting pt:242-250C
  Solubility:Ethanol: 6 mg/mL (11.35 mM); DMSO: 62 mg/mL (117.3 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Aggarwal S, et al. Steroids. 2010 Feb; 75(2):109-53.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting