• Product NameHydroxy Camptothecine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAn alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
• Target NameTopoisomerase inhibitor
• CAS No. 64439-81-2
• Calculated MW 364.35
• Formulation C20H16N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo I
  Boling pt:820.7C
  Melting pt:230-237C
  Solubility:Soluble in DMSO
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang S, et al. AntiY Drugs. 2014 Jul;25(6):614-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting