• Product NameDrospirenone
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityDrospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
• Target NameAndrogen Receptor antagonist; COX inhibitor; Estrogen/progestogen Receptor; Glucocorticoid Receptor antagonist
• CAS No. 67392-87-4
• Calculated MW 366.49
• Formulation C24H30O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@]5([C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7)C
  Pathways:Immunology/Inflammation; Endocrinology/Hormones; Neuroscience
  Receptor:Androgen Receptor; COX-2; PR; Mineralocorticoid Receptor
  Boling pt:552.2C
  Melting pt:196-200C
  Solubility:Ethanol: 11 mg/mL (30.01 mM); DMSO: 73 mg/mL (199.18 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bray JD, et al. J Steroid Biochem Mol Biol. 2005 Dec;97(4):328-41.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting