• Product NameLevamlodipine
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAmlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump.
• Target NameCalcium Channel inhibitor
• CAS No. 103129-82-4
• Calculated MW 408.88
• Formulation C20H25N2O5Cl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
  Pathways:Membrane transporter/Ion channel
  Receptor:Calcium Channel
  Boling pt:527.2C?
  Melting pt:102-104C
  Solubility:DMSO: 10 mM
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gui H, et al. CNS Neurosci Ther. 2013 Mar;19(3):178-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting